Studies on Antitumor Agents. III. Metabolites of 5 (4)-Amino-4 (5)-imidazolethiocarboxamide Derivatives in Urine
نویسندگان
چکیده
منابع مشابه
Pharmacological studies on 4 (or 5)-aminoimidazole-5 (or 4)-carboxamide (AICA) derivatives.
In previous works from our laboratory (1-3) we reported that 4-diazoimidazole-5 carboxamide (diazo-ICA) and 4-(mono or di-substituted) triazenoimidazole-5-carboxamide (mono or dialkyl-TICA) showed marked inhibitory effects on the growth of tumors and bacterial cells. During examination of their toxicity in mice, behavioral sedation caused by these compounds was also observed (2). These observat...
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متن کاملSynthesis and Characterization of Some Lanthanide(III) Chloro Complexes Derived from 4[N-(4’-Hydroxy-3’-Methoxybenzalidene) Amino] Antipyrine Semicarbazone and 4[N-(3’,4’,5’-Trimethoxybenzalidene) Amino]Antipyrine Semicarbazone
Lanthanide(III) chloro complexes of 4[N-(4’-hydroxy-3’-methoxybenzalidene) amino] antipyrine semicarbazone (HMBAAPS) (I) and 4[N-(3’,4’,5’-trimethoxybenzalidene) amino] antipyrine semicarbazone (TMBAAPS) (II) with the general composition LnCl3.2L (Ln = La, Pr, Nd, Sm, Gd, Tb, Dy or Ho; L = HMBAAPS or TMBAAPS) are reported. All the complexes were synthesized in ethanolic medium and refluxed the ...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1969
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.17.1720